The aim of the applied stem cell based disease modeling technologies is to conduct stem cell research, particularly within human induced pluripotent stem cells (hiPSCs) to study human developmental processes and disease under unique genetic patient-specific background. Stem cells also represent a source of cells for cell replacement therapy and serve as a platform for development of personalized gene therapies and drug screening. Cell fate reprogramming methods and differentiation of primary cells, including skin fibroblasts (derived by skin punch biopsies) and blood (peripheral blood mononuclear cells; PBMCs) are applied in the process. Below figures depicts general modeling work flow and levels of the complexity of the platform: